The world's first quantum-enabled EPR spectrometer.
See the protein dynamics that other techniques can't — with less sample, in less time, and without an EPR expert on staff.
New superconducting quantum-sensing resonator design enables accessible scientific discoveries and higher throughput than classical EPR.
Integrated Compact Package integrates key components into a compact design for efficient performance and easy maintenance.
Load-and-go automated reporting, multi-sample handling and an intuitive touchscreen interface designed for technician-level users.
Increase in sensitivity, speed and stability reduces EPR acquisition time from weeks to days.
New superconducting quantum-sensing resonator design enables accessible scientific discoveries and higher throughput than classical EPR.
Integrated Compact Package integrates key components into a compact design for efficient performance and easy maintenance.
Load-and-go automated reporting, multi-sample handling and an intuitive touchscreen interface designed for technician-level users.
Increase in sensitivity, speed and stability reduces EPR acquisition time from weeks to days.
From sample to results. No EPR expertise needed.
FATHOM was designed so that a laboratory technician and a trained EPR spectroscopist get the same results. Here's what a measurement looks like:
Pipette your sample
Load up to five samples into a High Q SQBA™ multi-sample cartridge — as little as 3.5 µL each, at micromolar concentrations.
Enter sample info in DEEP™
Name the sample and select the spin label type on FATHOM's purpose-built DEEP software interface. No parameter guessing required.
Load the cartridge and walk away
FATHOM automatically inserts the sample, optimizes its placement, and begins measuring. Serial batches run unattended — multiple cartridges per day are achievable.
Review results and export
DEEP calculates distance distributions in real time using industry-standard techniques. Export presentation-quality reports as PDF or raw data — with one click.
Built for the problems that matter most.
FATHOM delivers nanoscale distance distributions across a range of biophysical systems — from disordered proteins to large membrane complexes that NMR and Cryo-EM can't easily reach.
GPCRs & ligand-induced conformational changes
G-protein coupled receptors are the target of over 30% of FDA-approved drugs — yet their subtle conformational shifts are difficult to characterise. FATHOM's precise distance distributions reveal how GPCRs move upon ligand binding, giving drug hunters the structural insight needed to design better agonists and antagonists.
Protein–protein complexes & PROTACs
PROTACs and molecular glues work by forming ternary complexes — but characterising their geometry is notoriously hard. FATHOM provides intermolecular distance constraints that shed light on complex formation and quaternary structure, helping validate degrader efficacy on previously undruggable targets.
Intrinsically disordered proteins & dynamics
IDPs defy the classic structure-function model — and their flexibility makes them nearly invisible to NMR, Cryo-EM, and X-ray. FATHOM reports a full probability distribution of distances, capturing conformational ensembles and dynamic equilibria directly. Critical for neurodegenerative targets like amyloid-β and tau.
Cryo-EM & AlphaFold validation
AlphaFold predictions and Cryo-EM maps are powerful — but unverified models cost expensive instrument time. Use FATHOM to screen sample quality and conformation before you book time on the electron microscope. Point-to-point EPR distance constraints confirm or challenge predicted structures quickly and at low cost.
The software that makes FATHOM effortless.
Most scientific instruments hand complexity back to the user. DEEP™ was built to absorb it.
Simple, High-Throughput Workflow
DEEP's intuitive interface guides users from sample loading to distance distribution results without specialist knowledge. High Q's multi-sample cartridges enable efficient processing of multiple samples each day — with full walk-away capability between runs.
Automated, One-Click Analysis
Automated pre-acquisition checks verify sample quality before a run begins, catching problems before they cost you time. Real-time distance distribution calculations let you screen samples as they acquire. Export presentation-quality reports or raw data with a single click.
FATHOM and DEEP are intended for Research Use Only. Not for use in diagnostic procedures.
Ready to see FATHOM in action?
Our applications specialists will walk you through a demo, answer technical questions, and help you assess fit for your specific research program.