Advancing Biophysical EPR Performance
High Q systems combine superconducting resonator technology with quantum control algorithms to deliver sensitivity, stability, and flexibility that conventional EPR cannot match.
Precision pulse control, derived from quantum computing
Realizing the full potential of quantum devices requires a system built specifically to account for their unique properties. High Q spectrometers use modern digital electronics to achieve the stability and flexibility necessary to implement quantum control pulses with high fidelity.
Phase-stable AWG
Reduces or eliminates DEER distance measurement artifacts — a persistent problem in conventional EPR.
Noise-robust gates
Pulse sequences designed to be robust against environmental noise, borrowing directly from quantum computing gate design.
Flexible architecture
Modern digital electronics enable exploration and rapid development of novel EPR methodologies without hardware changes.
Instrument stability
Removes systematic bias and variance in long-running studies, enabling reliable multi-day or multi-sample campaigns.
Superconducting resonators that amplify signal, not noise
High Q EPR spectrometers use proprietary planar superconducting microstrip resonators. Unlike conventional loop-gap or dielectric resonators, these quantum devices harness superconducting materials to maximize the coupling between the microwave field and the spin sample.
What this means in practice
The combination of quantum control and quantum device hardware translates directly into measurable improvements over conventional EPR systems.
Sensitivity
Distance measurement times of low-concentration samples reduced from days to hours.
Instrument stability
Bias and variance removed in systematic studies for consistent, reproducible results.
Phase-stable AWG
Measurement artifacts reduced or eliminated — a persistent problem in conventional EPR.
Methodological flexibility
Novel EPR methodologies can be explored and developed without hardware limitations.
Ready to see FATHOM in action?
Our applications specialists will walk you through a demo, answer technical questions, and help you assess fit for your specific research program.
Built for the problems that matter most.
FATHOM® delivers nanoscale distance distributions across a range of biophysical systems — from disordered proteins to large membrane complexes that NMR and Cryo-EM can't easily reach.
GPCRs & ligand-induced conformational changes
G-protein coupled receptors are the target of over 30% of FDA-approved drugs — yet their subtle conformational shifts are difficult to characterise. FATHOM's precise distance distributions reveal how GPCRs move upon ligand binding, giving drug hunters the structural insight needed to design better agonists and antagonists.
Protein–protein complexes & PROTACs
PROTACs and molecular glues work by forming ternary complexes — but characterising their geometry is notoriously hard. FATHOM provides intermolecular distance constraints that shed light on complex formation and quaternary structure, helping validate degrader efficacy on previously undruggable targets.
Intrinsically disordered proteins & dynamics
IDPs defy the classic structure-function model — and their flexibility makes them nearly invisible to NMR, Cryo-EM, and X-ray. FATHOM reports a full probability distribution of distances, capturing conformational ensembles and dynamic equilibria directly. Critical for neurodegenerative targets like amyloid-β and tau.
Cryo-EM & AlphaFold validation
AlphaFold predictions and Cryo-EM maps are powerful — but unverified models cost expensive instrument time. Use FATHOM to screen sample quality and conformation before you book time on the electron microscope. Point-to-point EPR distance constraints confirm or challenge predicted structures quickly and at low cost.
Built on a decade of published science
High Q's technology is backed by peer-reviewed publications and protected by patents covering resonator design, quantum control algorithms, and EPR methodology.
Patents
Proprietary IP covers the superconducting resonator geometry, quantum control pulse design, and instrument integration — forming a defensible technology moat.
Scientific publications
Results from High Q instruments and foundational EPR methodology have been published in peer-reviewed journals. Customer stories demonstrate reproducible performance across labs.